Introducing Eyevistar®
A natural, standardized Tagetes erecta marigold extract containing 20% lutein and 4% zeaxanthin for advanced eye-health formulations.
Developed to support retinal integrity, macular carotenoid status and long-term visual performance.
Science-backed marigold extract for retinal health
Eyevistar®, made from marigold flower extract derived from Tagetes erecta L., is a standardized carotenoid ingredient containing 20% lutein and 4% zeaxanthin. Lutein and zeaxanthin are naturally occurring xanthophyll carotenoids that concentrate in the macular region of the eye, where they contribute to macular pigment formation, filter high-energy blue light and help neutralize reactive oxygen species.
Eyevistar has been evaluated through in-vitro and in-vivo studies for its antioxidant, cytoprotective and anti-lipofuscin properties. It is intended for use in dietary supplements and nutraceutical formulations developed to support retinal integrity, macular health and long-term visual performance.
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Everything a formulator needs to evaluate Eyevistar®
A defined carotenoid composition
Lutein
Standardization: 20%
A xanthophyll carotenoid that contributes to macular pigment, helps filter high-energy blue light and supports antioxidant protection within retinal tissues.
Learn About Lutein→Zeaxanthin
Standardization: 4%
A macular carotenoid concentrated in the central retina, where it supports visual function and helps protect retinal structures from oxidative and phototoxic stress.
Learn About Zeaxanthin→Marigold Carotenoid Matrix
Botanical source: Tagetes erecta L.
Marigold flowers are a commercially important botanical source of lutein and zeaxanthin used in standardized eye-health ingredients.
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Formulated around the biology of the macula
Supports Retinal Integrity
Helps maintain retinal pigment epithelial cell function and retinal architecture under oxidative stress conditions.
Promotes Macular Carotenoid Status
Supports the delivery and deposition of lutein and zeaxanthin in plasma and macular tissue.
Provides Antioxidant Defence
Supports antioxidant capacity and the activity of protective enzymes including SOD, CAT and glutathione peroxidase.
Helps Control Lipofuscin Accumulation
Demonstrated reductions in A2E and lipofuscin accumulation in preclinical retinal models.
Supports Long-Term Visual Performance
Provides the macular carotenoids required for blue-light filtration and protection against retinal oxidative stress.
Supports Healthy Retinal Stress Response
Preclinical findings showed modulation of retinal and mitochondrial stress-related markers, including VEGF, HSP60 and ARMS2.
Measured in retinal cells and animal models
Retinal Cell Study
In ARPE-19 retinal pigment epithelial cells, Eyevistar increased cell proliferation by 33.59%, 46.15% and 62.31% at concentrations of 125, 250 and 500 µg/mL, respectively.
Following UV exposure, Eyevistar supported cell viability of 81.19% at 250 µg/mL and 100.64% at 500 µg/mL. It also reduced UV-induced A2E accumulation and decreased the presence of lipofuscin granules observed through transmission electron microscopy.
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Proliferation at 125 µg/mL
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Proliferation at 250 µg/mL
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Proliferation at 500 µg/mL
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Post-UV cell viability at 250 µg/mL
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Post-UV cell viability at 500 µg/mL
In-Vivo Evaluation
In a 42-day high-fat-diet animal model, Eyevistar was administered at 2.5, 5 and 10 mg/kg body weight. The 10 mg/kg group showed the strongest restoration of plasma and macular lutein and zeaxanthin levels, together with improvements in antioxidant biomarkers, retinal architecture and lipofuscin accumulation.
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Research Status
A double-blind, placebo-controlled human study evaluating lutein and zeaxanthin for macular pigment optical density, photostress recovery, glare disability and contrast sensitivity is ongoing.
Documentation for your evaluation
Developed and Manufactured by Star Hi Herbs Pvt. Ltd.
Star Hi Herbs Pvt. Ltd. develops and manufactures standardized botanical extracts, branded nutraceutical ingredients and research-supported formulations for the dietary supplement, food, pharmaceutical and wellness industries. Eyevistar is manufactured and registered by Star Hi Herbs Pvt. Ltd., with research conducted through its R&D department in Bangalore in collaboration with external research institutions.
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